|
KMID : 0545120100200030622
|
|
Journal of Microbiology and Biotechnology
2010 Volume.20 No. 3 p.622 ~ p.629
|
|
|
Biosynthesis of phenylpropanoid amides by an endophytic Penicillium brasilianum found in root bark of Melia azedarach
|
|
Fill Taicia Pacheco
Da Silva Bianca Ferreira
Rodrigues-Fo Edson
|
|
|
Abstract
|
|
|
|
Biosynthetic studies on brasiliamides, potently convulsive and bacteriostatical compounds from an endophytic Penicillium brasilianum isolated from Melia azedarach (Meliaceae), confirms their phenylpropanoid origin which is very uncommon in fungi. Feeding experiments with [2-13C]-Phenylalanine indicated the incorporation of two units of this amino acid on brasiliamide structures. The first step in phenylpropanoid pathway to those compounds was evaluated through enzymatic bioassays and confirmed the Phenylalanine Ammonia-Lyase (PAL) participation. The metabolism of phenylalanine in this fungus is discussed.
|
|
|
KEYWORD
|
|
|
Biosynthesis, Phenylpropanoid, Penicillium, Endophytic, Bis-phenylpropanoyl amides, Isotoically labelled
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|